Harsher Covid restrictions now apply to millions more people, as rule changes come into force across the UK.
Around six million people in east and south-east England have gone into tier four, England's highest Covid level - which includes a "stay at home" order.
Lockdowns have also started in Scotland and Northern Ireland, and measures have been reimposed in Wales after being eased for Christmas.
It comes after official UK coronavirus deaths
passed 70,000 on Christmas Day.
The toughest measures - which mean the closure of all non-essential shops, as well as hairdressers, swimming pools and gyms - now apply to around 24 million people in England, more than 40% of the population.
Prof Devi Sridhar, chairwoman of global public health at the University of Edinburgh, told the BBC she believed all of England was likely to be soon be in tier four.
"I think that's where it's heading and it's better to be honest with people so they can plan the next few weeks to understand what might be coming," she said, adding: "To really keep a handle on these numbers, you need to move early."
The whole of Sussex, Oxfordshire, Suffolk, Norfolk and Cambridgeshire, as well Essex, Waverley in Surrey, and all of Hampshire with the exception of the New Forest, are now in tier four.
Bristol, Gloucestershire, Somerset, Swindon, the Isle of Wight, the New Forest and Northamptonshire, as well as Cheshire and Warrington, have all moved up to tier three. Meanwhile, Cornwall and Herefordshire have moved from tier one to tier two.
Tier four restrictions mean shops in many town and city centres have been closed for the first time in decades on Boxing Day, when there are usually sales.
Even some retailers deemed "essential" - such as Asda - have opted not to open.
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Covid-19: Tougher Covid rules begin for millions in UK - BBC News