It makes no difference as it's the expressed volume which is the difference between plunger position, so as long as the needle has been primed the dose is the same. These days we use filter needles to draw up the dose, then swap to the needle for injection, prime and inject. Or if there's a cannula or butterfly in place we don't use a needle at all - though it's important then to flush through as there's quite a lot of dead space, particularly with sub cut butterfly lines.Hi Anna are syringes calibrated with the needle on or off as this would be critical for medical purposes.
I am guessing the ones for dispensing medicine (for children)are calibrated without syringes
Asking for a friend
@The Baron yep, the needle hub contains the relevant drug.
Anyway... a bit off topic.