Continued....
It’s my view based on a complex calculation, which may be wrong, that roughly 28% had been. But these estimates are at least in the same range, and this is about to be crucial, too. Other epidemiologists, including some who are regarded as world leading, have crunched numerous formulae. They show that, with the extent of prior immunity that we now know about, only 15-25% of the population is completely sufficient to bring the spread of the virus to a shuddering halt. There are a couple of final scientific but sad components to this horrible understanding. We saw, early on in the pandemic, the number of daily deaths absolutely soar. We did not know then where it would stop rising. But we do now have a good explanation for the very steep rise & much slower fall. It’s that it’s been shown previously, and we appeared to have forgotten it, that the most easily infected people got infected earliest. Sounds obvious & in a way, it is. We vary hugely, not only in our responses to viruses, but also in the ease or difficulty the virus finds as it tries to invade us. The most susceptible were those already elderly and/or ill, some very ill, and so we saw very high death rates initially. Once that super-susceptible group were consumed by the virus, it began a slower march through everyone else, slowing all the time, as the % susceptible fell & fell towards the herd immunity threshold. That is where we now are & that is why the virus is disappearing from the environment. While there are some ‘cases’ they are the hardest to infect & I think in large measure they are mostly the least vulnerable medically. That’s why deaths have almost ceased, having fallen over 99% from peak. All the numbers monitored carefully fallen like this, too: the numbers being hospitalised, numbers in hospital, number in intensive care, all way to 99% lower than peak.
You might be asking, where is the 2nd peak? The truth is, that generally doesn’t happen. You don’t generally get infected by the exact same virus twice, certainly not close in time. It’d be a poor immune system which let that happen & we’d probably not have made it to the 21st century if that’s how it worked. So there’s an expectation of some duration of immunity. It needs studying, but my experience suggests it you’ve memory T-cells, durability can be very long. One small study showed that people had robust T-cell responses to the first SARS & that was 2003! So what now? Well, the tests we’ve used to date have served us well. The PCR test for virus is good enough to confirm infection in someone with symptoms. Is it flu or is it covid19 was easily answered. What it’s very poor at is what is being asked of it now, in mass, community testing. We don’t know exactly what the false positive rate is, but it is widely believed to be greater that the actual, remaining prevalence of the virus! The result of continuing to use this test alone is to generate a high proportion of false positives. Note that recent so-called’spikes’ were never accompanied or followed by people getting ill, going to hospital & dying in elevated numbers. I truly believe most of the positives from mass testing are false ones. I don’t think the test now helps us at all & IMO it should immediately cease.
A couple of closing points, which I can’t ignore, even though they’re embarrassing & some are totally tragic and scandalous. First, lockdown. I think there is no solid evidence that it played any role in slowing transmission. That’s not so terribly surprising because a little later, we realised that the vast bulk of transmission was going on in & around hospitals & care homes. This is no criticism: it’s where ill people are & these viruses are almost impossible to prevent moving between people. But given that, general lockdown simply couldn’t be a big factor bearing down on the pandemic. Knowing what we know, we don’t need to conceive lots of transmission going on between strangers in the street. Different on the Tube, I shouldn’t wonder, but in general, it is my view that we needn’t have locked down. I’m going to confess at this point that I myself was scared around that time. I’m accepting that had I been anywhere near that big call, I would have voted for the 1st lockdown & possibly the first extension. Beyond there I believe it was abundantly clear we were gaining nothing from it & we were destroying the economy as well as people’s spirit & mental health. I was truly shocked at recent lockdowns: by then it was certain they don’t work & in any case at that point the pandemic was drawing to a close, less & less lethally. The other point I’d make is that the evidence that masks, especially cheap face cloths, block transmission is extremely weak. In the one really large, properly randomised study of respiratory virus transmission generally, the evidence was stark: the worst outcomes was in the group using face coverings. I don’t think the evidence of harm is other than weak, either. But they’re not useful. My final blast is I’m afraid at the position of the NHS. I say right now, it’s not the NHS I blame for its state, but those who’ve asked that it remain ‘Covid19 ready’. The only explanation I can think of is that our Govt sincerely believes there’ll be a 2nd wave. I don’t think that at all & no scientist I’ve conversed with thinks so, either. It’s tragic that there is no doubt at all that a large number of people have died avoidable deaths in recent months. I don’t have any means to assess this, but I’ve heard that, if this position isn’t changed in the next four weeks & certainly long before winter, the effect of our responses to this virus could kill as many people as the virus already has.
We have good & improving tests, for covid19, influenza, respiratory syncytial virus & more. If we get excess winter deaths, which every country in our latitude does, we will be able to diagnose what they suffered from. The virus can’t sneak up on us. If it emerges, we will spot it before it spreads. I expect there will be local, small & self limiting mini outbreaks, hopefully without many deaths. But we must see our precious NHS orientated back to its normal shape & excellent services. I salute those brave NHS staff & care home workers who kept on going to work, especially early on, when we knew too little to guarantee their safety. That’s courage, professionalism & humanity right there. Thank you. So in closing, what are my hopes? I sincerely hope seniors advising HMG discuss all this, not only with me (I’m a retired scientist with no profile & no wish for one) but with some of the authors of the papers i mentioned by haven’t formally referenced here. I’m helping craft a formal Advisory paper which I hope will be considered in the coming v few weeks. We need to move fast, but the thinking must be honestly pressure tested. All I hope for are 3 things: normalise the NHS by end-Sept; halt random mass testing within two weeks; lift the mask mandate (please). In finishing, please note that every single one of these observations & ideas, (most of which belong not to me, but the scientists who provided the scaffold for this climb), are being cognitated & ruminated on by our peers in all heavily infected countries. I don’t know what the position is outside a handful of European countries. But people in France, Italy, dare I say Sweden, may have differing or convergent views. So some intergovernmental talking is probably in order.